Publications

2026

An inherited hypomorphic PIEZO2 variant reveals structural features of mechanotransduction

Nickolls AR, Mulhall EM, Orlin DJ, Yarishkin O, Romero LO, Bell B, Hu X, Madden CA, Hardy RR, O’Brien GS, Donkervoort S, Saade DN, Lehyk TJ, Foley R, Bharucha-Goebel DX, Dastgir J, Vásquez V, Cordero-Morales JF, Bönnemann CG, Patapoutian A, Falgairolle M, and Chesler AT. (2026) Neuron

The Molecular Basis of Force Selectivity by PIEZO2

Mulhall EM, Yarishkin O, Hill RZ, Koster AK, and Patapoutian A. (2026) Nature

2024

PCDH15 dual-AAV gene therapy for deafness and blindness in Usher syndrome type 1F models

Ivanchenko MV, Hathaway DM, Mulhall EM, Booth KT, Wang M, Peters CW, Klein AJ, Chen X, Li Y, György B, and Corey DP. (2024) Journal of Clinical Investigation

2023

Direct Observation of the Conformational States of PIEZO1

Mulhall EM, Gharpure A, Lee RM, Dubin AE, Aaron JS, Marshall KL, Spencer KR, Reiche MA, Henderson SC, Chew T-C, and Patapoutian A. (2023) Nature

Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F

Ivanchenko MV, Hathaway DM, Klein AJ, Pan B, Strelkova O, De-la-Torre P, Wu X, Peters CW, Mulhall EM, Booth KT, Goldstein C, Brower J, Sotomayor M, Indzhykulian AA, and Corey DP. (2023) Nature Communications

2021

Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection

Mulhall EM, Ward AW, Yang D, Koussa MA, Corey DP, and Wong WP. (2021) Nature Communications

2018

An evolutionarily conserved gene family encodes proton-selective ion channels

Tu Y, Cooper AJ*, Teng B*, Chang RB*, Artiga DJ, Turner HM, Mulhall EM, Ye W, Smith AD, and Liman ER. (2018) Science

2016

The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction.

Ye W, Chang RB, Bushman JD, Tu Y, Mulhall EM, Wilson CE, Cooper AJ, Chick WS, Hill-Eubanks DC, Nelson MT, Kinnamon SC, and Liman ER. (2016) Proceedings of the National Academy of Sciences USA